The scientist discovers the molecular mechanism of blemish of gene of purify red blood cell

The cent pickaback plane of RNA of messenger of the defective in coming from the scientist of Pennsylvania university college of medicine to discover one kind probes red blood cell of alternative purify is made. Other is similar mechanism consist in in a variety of cells. Understand this kind of system to be able to help us understand transmissibility disease very much more, for example mediterranean exsanguine.
? ? result is published in newest " Nature Structural And Molecular Biology " go up.
? ? cell uses this kind of surveillance to the mechanism will find and destroy unusual RNA. The wrong misunderstanding when RNA compiles albumen produces unusual protein, this causes cellular function finally unusual die even.
The mediterranean that group of ? ? Penn studies anaemia is caused as a result of gene mutation, this makes the protein that cellular ribosome produces too long. And mediterranean anaemic expression produces an amount to be not worth for hematin albumen -- this is the member that oxygen carries in blood. The mutation of team analysis is a kind of gene that in southeast Asia know exactly about sth 1 million people carry, it is the main reason that causes fetal death and grown disease.
Counted in the past year the scientist had found several surveillant mechanisms, they are in charge of identifying the specific mutation of RNA. For example a kind of the commonnest mechanism identifying is not had justice choppy, this meeting brings about RNA to had produced short protein. Without justice mutation can bring about flesh to be changed with cyst fiber feebly wait for a disease.
One of ? ? main authors Stephen A. Liebhaber expresses: "We described the surveillant way that is aimed at the RNA that exists in red blood cell only. " and Jian of the first author Kong says: "This kind of mechanism is organizing a level by adjusting control, and in the cell that at the same time height of consist in other splits up. Understand this one mechanism to be able to help us understand a variety of gene very much more unusual. Understand this one mechanism to be able to help us understand a variety of gene very much more unusual..
Hope of ? ? Liebhaber studies this kind of surveillant mechanism will analyse further why it is aimed at red blood cell only, this kind of information can be helped search hold the means that charges these systems to treat diseases of a variety of red blood cell.
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